Force staircase kinetics in mammalian cardiac muscle: modulation by muscle length
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چکیده
منابع مشابه
Ca2+ and segment length dependence of isometric force kinetics in intact ferret cardiac muscle.
The influence of Ca2+ and sarcomere length on myocardial crossbridge kinetics was studied in ferret papillary muscle by measuring the rate of force redevelopment following a rapid length step that dropped the force to zero. Tetanic stimulation with 5 mumol/L ryanodine was used to obtain a steady-state contraction, and segment length was measured and controlled using a sense-coil technique that ...
متن کاملStaircase in mammalian muscle without light chain phosphorylation.
In disuse atrophied skeletal muscle, the staircase response is virtually absent and light chain phosphorylation does not occur. The purpose of the present study was to determine if staircase could be restored in atrophied muscle with continued absence of myosin light chain phosphorylation, by reducing what appears to be an otherwise enhanced calcium release. Control (untreated) and sham-operate...
متن کاملEffect of muscle length on the force-velocity relationship of tetanized cardiac muscle.
Cat papillary muscles were tetanized with repetitive electrical stimulation in the presence of 10 ITIM caffeine and 10 mM calcium. Velocities were measured during the plateau of tetanus with quick releases to isotonic loads. The course of isotonic shortening was independent of time in the contraction cycle for at least 2 seconds after the attainment of peak isometric force. The force-velocity r...
متن کاملForce-velocity relations in mammalian heart muscle.
SONNENBLICK, EDMUND H. Force-velocity relations in mammalian heart muscle. Am. J. Physiol. 202 (5) : 931-939. 1962.Force-velocity relations were studied in the cat papillary muscle. As with skeletal muscle, a characteristic relation has been demonstrated between the velocity of shortening (V) and the force developed (PO). Two generalities have been shown to pertain. First, increasing initial mu...
متن کاملAlterations in resting length-tension relations of cardiac muscle induced by changes in contractile force.
Effects of sustained postextrasystolic potentiation (P.S.), norepinephrine (NE), and calcium on resting length-tension relations of heart muscle were studied in the cat papillary muscle and isovolumic dog ventricle. In papillary muscles, P.S., calcium or NE produced no change in diastolic compliance when the muscles were freely isotonic, or afterloaded, and force remained constant. However, und...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1980
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1980.sp013128